Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia
Identifieur interne : 000711 ( Main/Exploration ); précédent : 000710; suivant : 000712Frontal and associative visual areas related to visual hallucinations in dementia with Lewy bodies and Parkinson's disease with dementia
Auteurs : Cristina Sanchez-Castaneda [Espagne] ; Ramon Rene [Espagne] ; Blanca Ramirez-Ruiz [Espagne] ; Jaume Campdelacreu [Espagne] ; Jordi Gascon [Espagne] ; Carles Falcon [Espagne] ; Matilde Calopa [Espagne] ; Serge Jauma [Espagne] ; Montserrat Juncadella [Espagne] ; Carme Junque [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
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Abstract
Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22873
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="615">615</biblScope><biblScope unit="page" to="622">622</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8AB3E1F2E6A5077028126E8A376035630A9A4C85</idno><idno type="DOI">10.1002/mds.22873</idno><idno type="ArticleID">MDS22873</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy Body disease</term><term>MRI</term><term>Parkinson's disease</term><term>VBM</term><term>dementia</term><term>visual hallucinations</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel‐based morphometry and behavioral assessment to 12 clinically diagnosed DLB patients and 15 PDD patients. Subjects with VH showed greater gray matter loss than non‐hallucinators, specifically in the right inferior frontal gyrus (BA 45) in the DLB patients and in the left orbitofrontal lobe (BA 10) in the PDD patients. Comparing the two subgroups with VH, DLB patients had greater decrease of the bilateral premotor area (BA 6) than PDD patients. Furthermore, decreased volume in associative visual areas, namely left precuneus and inferior frontal lobe, correlated with VH in the DLB but not in PDD patients. VH were related to impaired verbal fluency, inhibitory control of attention and visuoperception in the DLB group and to visual memory in the PDD group. In conclusion, DLB and PDD patients with VH had more frontal gray matter atrophy than non‐hallucinators, the impairment being greater in the DLB group. The patterns of structural and functional correlations were different in both pathologies. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Sanchez Astaneda, Cristina" sort="Sanchez Astaneda, Cristina" uniqKey="Sanchez Astaneda C" first="Cristina" last="Sanchez-Castaneda">Cristina Sanchez-Castaneda</name></region><name sortKey="Calopa, Matilde" sort="Calopa, Matilde" uniqKey="Calopa M" first="Matilde" last="Calopa">Matilde Calopa</name><name sortKey="Campdelacreu, Jaume" sort="Campdelacreu, Jaume" uniqKey="Campdelacreu J" first="Jaume" last="Campdelacreu">Jaume Campdelacreu</name><name sortKey="Falcon, Carles" sort="Falcon, Carles" uniqKey="Falcon C" first="Carles" last="Falcon">Carles Falcon</name><name sortKey="Gascon, Jordi" sort="Gascon, Jordi" uniqKey="Gascon J" first="Jordi" last="Gascon">Jordi Gascon</name><name sortKey="Jauma, Serge" sort="Jauma, Serge" uniqKey="Jauma S" first="Serge" last="Jauma">Serge Jauma</name><name sortKey="Juncadella, Montserrat" sort="Juncadella, Montserrat" uniqKey="Juncadella M" first="Montserrat" last="Juncadella">Montserrat Juncadella</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Ramirez Uiz, Blanca" sort="Ramirez Uiz, Blanca" uniqKey="Ramirez Uiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name><name sortKey="Rene, Ramon" sort="Rene, Ramon" uniqKey="Rene R" first="Ramon" last="Rene">Ramon Rene</name><name sortKey="Sanchez Astaneda, Cristina" sort="Sanchez Astaneda, Cristina" uniqKey="Sanchez Astaneda C" first="Cristina" last="Sanchez-Castaneda">Cristina Sanchez-Castaneda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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